Delayed reorganisation of F-actin cytoskeleton and reversible chromatin condensation in scleral fibroblasts under simulated pathological strain.

ABSTRACT: Mechanical loading regulates the functional capabilities of the ocular system, particularly in the sclera ('white of the eye') - the principal load-bearing tissue of the ocular globe. Resident fibroblasts of the scleral eye wall are continuously subjected to fluctuating mechanical strains arising from eye movements, cerebrospinal fluid pressure and, most influentially, intra-ocular pressure (IOP). Whilst fibroblasts are hypothesised to actively participate in scleral biomechanics, to date limited information has been reported on how the macroscopic stresses and strains are transmitted via their cytoskeletal networks. In this study, the effect of applying either a 'physiological load' (simulating healthy IOP) or a 'pathological load' (simulating an elevated glaucomatous IOP) t

SUBMITTER: Markov P 

PROVIDER: S-EPMC9482111 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature