Specific immunosuppressive role of nanodrugs targeting calcineurin in innate myeloid cells.

ABSTRACT: Calcineurin (CN) inhibitors currently used to avoid transplant rejection block the activation of adaptive immune responses but also prevent the development of tolerance toward the graft, by directly inhibiting T cells. CN, through the transcription factors of the NFAT family, plays an important role also in the differentiation dendritic cells (DCs), the main cells responsible for the activation of T lymphocytes. Therefore, we hypothesized that the inhibition of CN only in DCs and not in T cells could be sufficient to prevent T cell responses, while allowing for the development of tolerance. Here, we show that inhibition of CN/NFAT pathway in innate myeloid cells, using a new nanoconjugate capable of selectively targeting phagocytes in vivo, protects against graft rejection and induc

SUBMITTER: Colombo M 

PROVIDER: S-EPMC9482116 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature