Estimating mean potential outcome under adaptive treatment length strategies in continuous time.

ABSTRACT: An adaptive treatment length strategy is a sequential stage-wise treatment strategy where a subject's treatment begins at baseline and one chooses to stop or continue treatment at each stage provided the subject has been continuously treated. The effects of treatment are assumed to be cumulative and, therefore, the effect of treatment length on clinical endpoint, measured at the end of the study, is of primary scientific interest. At the same time, adverse treatment-terminating events may occur during the course of treatment that require treatment be stopped immediately. Because the presence of a treatment-terminating event may be strongly associated with the study outcome, the treatment-terminating event is informative. In observational studies, decisions to stop or continue treatment dep

SUBMITTER: Sun H 

PROVIDER: S-EPMC9482146 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature