BladMetrix: a novel urine DNA methylation test with high accuracy for detection of bladder cancer in hematuria patients.

ABSTRACT:

Background

Cystoscopy is the gold standard for bladder cancer detection, but is costly, invasive and has imperfect diagnostic accuracy. We aimed to identify novel and accurate DNA methylation biomarkers for non-invasive detection of bladder cancer in urine, with the potential to reduce the number of cystoscopies among hematuria patients.

Results

Biomarker candidates (n = 32) were identified from methylome sequencing of urological cancer cell lines (n = 16) and subjected to targeted methylation analysis in tissue samples (n = 60). The most promising biomarkers (n = 8) were combined into a panel named BladMetrix. The performance of BladMetrix in urine was assessed in a discovery series (n = 112), consisting of bladder cancer patients, patients with other urological cancers and

SUBMITTER: Pharo HD 

PROVIDER: S-EPMC9482155 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature