Diminished antiviral innate immune gene expression in the placenta following a maternal SARS-CoV-2 infection.

ABSTRACT:

Background

COVID-19 is caused by the SARS-CoV-2 virus and is associated with critical illness requiring hospitalization, maternal mortality, stillbirth, and preterm birth. SARS-CoV-2 has been shown to induce placental pathology. However, substantial gaps exist in our understanding of the pathophysiology of COVID-19 disease in pregnancy and the long-term impact of SARS-CoV-2 on the placenta and fetus. To what extent a SARS-CoV-2 infection of the placenta alters the placental antiviral innate immune response is not well understood. A dysregulated innate immune response in the setting of maternal COVID-19 disease may increase the risk of inflammatory tissue injury or placental compromise and may contribute to deleterious pregnancy outcomes.

Objective

We sought to determine the

SUBMITTER: Coler B 

PROVIDER: S-EPMC9482164 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature