Sex differences in number of X chromosomes and X-chromosome inactivation in females promote greater variability in hearing among males.

ABSTRACT:

Background

For more than 150 years, research studies have documented greater variability across males than across females ("greater male variability"-GMV) over a broad range of behavioral and morphological measures. In placental mammals, an ancient difference between males and females that may make an important contribution to GMV is the different pattern of activation of X chromosomes across cells in females (mosaic inactivation of one the two X chromosomes across cells) vs males (consistent activation of a single X chromosome in all cells). In the current study, variability in hearing thresholds was examined for human listeners with thresholds within the normal range. Initial analyses compared variability in thresholds across males vs. across females. If greater across-male than

SUBMITTER: Summers V 

PROVIDER: S-EPMC9482204 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature