The role of DNA demethylation in liver to pancreas transdifferentiation.

ABSTRACT:

Background

Insulin producing cells generated by liver cell transdifferentiation, could serve as an attractive source for regenerative medicine. The present study assesses the relationship between DNA methylation pTFs induced liver to pancreas transdifferentiation.

Results

The transdifferentiation process is associated with DNA demethylation, mainly at gene regulatory sites, and with increased expression of these genes. Active inhibition of DNA methylation promotes the pancreatic transcription factor-induced transdifferentiation process, supporting a causal role for DNA demethylation in this process.

Conclusions

Transdifferentiation is associated with global DNA hypomethylation, and with increased expression of specific demethylated genes. A combination of epigenetic m

SUBMITTER: Har-Zahav A 

PROVIDER: S-EPMC9482206 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature