DNA methylation and aeroallergen sensitization: The chicken or the egg?

ABSTRACT:

Background

DNA methylation (DNAm) is considered a plausible pathway through which genetic and environmental factors may influence the development of allergies. However, causality has yet to be determined as it is unknown whether DNAm is rather a cause or consequence of allergic sensitization. Here, we investigated the direction of the observed associations between well-known environmental and genetic determinants of allergy, DNAm, and aeroallergen sensitization using a combination of high-dimensional and causal mediation analyses.

Methods

Using prospectively collected data from the German LISA birth cohort from two time windows (6-10 years: N = 234; 10-15 years: N = 167), we tested whether DNAm is a cause or a consequence of aeroallergen sensitization (specific immunoglobuli

SUBMITTER: Kilanowski A 

PROVIDER: S-EPMC9482323 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature