Structure and mechanism of the SGLT family of glucose transporters.

ABSTRACT: Glucose is a primary energy source in living cells. The discovery in 1960s that a sodium gradient powers the active uptake of glucose in the intestine¹ heralded the concept of a secondary active transporter that can catalyse the movement of a substrate against an electrochemical gradient by harnessing energy from another coupled substrate. Subsequently, coupled Na⁺/glucose transport was found to be mediated by sodium-glucose cotransporters^2,3 (SGLTs). SGLTs are responsible for active glucose and galactose absorption in the intestine and for glucose reabsorption in the kidney⁴, and are targeted by multiple drugs to treat diabetes⁵. Several members within the SGLT family transport key metabolites other than glucose². Here we r

SUBMITTER: Han L 

PROVIDER: S-EPMC9482448 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature