Pioglitazone Mediates Cardiac Progenitor Formation through Increasing ROS Levels.

ABSTRACT: In order to achieve a sufficient population of cardiac-committed progenitor cells, it is crucial to know the mechanisms of cardiac progenitor formation. Previous studies suggested ROS effect on cardiac commitment events to play a key role in the cell signaling and activate cardiac differentiation of pluripotent stem cells. We previously reported that PPARγ activity is essential for cardiac progenitor cell commitment. Although several studies have conducted the involvement of PPARγ-related signaling pathways in cardiac differentiation, so far, the regulatory mechanisms of these signaling pathways have not been discussed and cleared. In this study, we focus on the role of PPARγ agonist in ROS generation and its further effects on the differentiation of cardiac cells from

SUBMITTER: Baharlooie M 

PROVIDER: S-EPMC9482506 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature