Use of ketamine in patients with refractory severe asthma exacerbations: systematic review of prospective studies.

ABSTRACT:

Purpose

Asthma is a heterogeneous disease with a wide range of symptoms. Severe asthma exacerbations (SAEs) are characterized by worsening symptoms and bronchospasm requiring emergency department visits. In addition to conventional strategies for SAEs (inhaled β-agonists, anticholinergics, and systemic corticosteroids), another pharmacological option is represented by ketamine. We performed a systematic review to explore the role of ketamine in refractory SAEs.

Methods

We performed a systematic search on PubMed and EMBASE up to August 12th, 2021. We selected prospective studies only, and outcomes of interest were oxygenation/respiratory parameters, clinical status, need for invasive ventilation and effects on weaning.

Results

We included a total of seven studies, five

SUBMITTER: La Via L 

PROVIDER: S-EPMC9482594 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature