Computational Model of the Effect of Mitochondrial Dysfunction on Excitation-Contraction Coupling in Skeletal Muscle.

ABSTRACT: It has become well established that mitochondria not only regulate myoplasmic calcium in skeletal muscle, but also use that calcium to stimulate oxidative phosphorylation (OXPHOS). While experimental approaches have allowed for imaging of mitochondrial calcium and membrane potentials in isolated fibers, capturing the role of mitochondria and the impact of mitochondrial impairments on excitation-contraction coupling (ECC) remains difficult to explore in intact muscle. Computational models have been widely used to examine the structure and function of skeletal muscle contraction; however, models of ECC to date lack communication between the myoplasm and mitochondria for regulating calcium and ATP during sustained contractions. To address this, a mathematical model of mitochondrial calcium ha

SUBMITTER: Senneff S 

PROVIDER: S-EPMC9482608 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature