Pregnancy loss and the risk of rheumatoid arthritis in Chinese women: findings from the China Kadoorie biobank.

ABSTRACT: Considering the female preponderance of rheumatoid arthritis (RA), and disease onset typically after the reproductive years, pregnancy and childbirth may play a role in the aetiology of the disease. Adverse outcomes of pregnancy have been found to precede the diagnosis of autoimmune diseases, including RA, but the evidence is scant and inconsistent. Therefore, we investigate whether pregnancy loss is associated with the risk of RA in Chinese women. Data from the China Kadoorie Biobank, conducted by the University of Oxford and the Chinese Centre for Disease Control and Prevention, of 299,629 Chinese women who had been pregnant were used. Multivariable logistic regression and stratified analyses were employed to analyse the association between types of pregnancy loss with the risk of RA. Pr

SUBMITTER: Hee JY 

PROVIDER: S-EPMC9482729 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature