Myocardial effects of angiotensin II compared to norepinephrine in an animal model of septic shock.

ABSTRACT:

Background

Angiotensin II is one of the vasopressors available for use in septic shock. However, its effects on the septic myocardium remain unclear. The aim of the study was to compare the effects of angiotensin II and norepinephrine on cardiac function and myocardial oxygen consumption, inflammation and injury in experimental septic shock.

Methods

This randomized, open-label, controlled study was performed in 20 anesthetized and mechanically ventilated pigs. Septic shock was induced by fecal peritonitis in 16 animals, and four pigs served as shams. Resuscitation with fluids, antimicrobial therapy and abdominal drainage was initiated one hour after the onset of septic shock. Septic pigs were randomly allocated to receive one of the two drugs to maintain mean arterial pressu

SUBMITTER: Garcia B 

PROVIDER: S-EPMC9482744 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature