Exercise training enhances muscle mitochondrial metabolism in diet-resistant obesity.

ABSTRACT:

Background

Current paradigms for predicting weight loss in response to energy restriction have general validity but a subset of individuals fail to respond adequately despite documented diet adherence. Patients in the bottom 20% for rate of weight loss following a hypocaloric diet (diet-resistant) have been found to have less type I muscle fibres and lower skeletal muscle mitochondrial function, leading to the hypothesis that physical exercise may be an effective treatment when diet alone is inadequate. In this study, we aimed to assess the efficacy of exercise training on mitochondrial function in women with obesity with a documented history of minimal diet-induced weight loss.

Methods

From over 5000 patient records, 228 files were reviewed to identify baseline characterist

SUBMITTER: Pileggi CA 

PROVIDER: S-EPMC9482931 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature