Clinical application status and prospect of the combined anti-tumor strategy of ablation and immunotherapy.

ABSTRACT: Image-guided tumor ablation eliminates tumor cells by physical or chemical stimulation, which shows less invasive and more precise in local tumor treatment. Tumor ablation provides a treatment option for medically inoperable patients. Currently, clinical ablation techniques are widely used in clinical practice, including cryoablation, radiofrequency ablation (RFA), and microwave ablation (MWA). Previous clinical studies indicated that ablation treatment activated immune responses besides killing tumor cells directly, such as short-term anti-tumor response, immunosuppression reduction, specific and non-specific immune enhancement, and the reduction or disappearance of distant tumor foci. However, tumor ablation transiently induced immune response. The combination of ablation and immunothera

SUBMITTER: Yin L 

PROVIDER: S-EPMC9483102 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature