Serum Metrnl levels are decreased in subjects with overweight or obesity and are independently associated with adverse lipid profile.

ABSTRACT:

Background

Meteorin-like (Metrnl), a novel adipokine, is highly expressed in adipose tissue and has a beneficial effect on energy metabolism. However, data on circulating Metrnl levels in obesity are scarce and inconsistent. This study aimed to evaluate the serum levels of Metrnl in adults with obesity and its association with glucose and lipid metabolism.

Methods

182 subjects were included in the cross-sectional study. The participants were divided into three groups according to BMI: normal (n = 95), overweight (n = 46), and obesity (n = 41). Serum Metrnl concentrations were measured by enzyme-linked immunosorbent assay.

Results

Serum Metrnl levels in overweight or obese subjects were significantly lower than in the normal group. Circulating Metrnl levels were negati

SUBMITTER: Ding X 

PROVIDER: S-EPMC9483104 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature