Schisantherin A alleviates non-alcoholic fatty liver disease by restoring intestinal barrier function.

ABSTRACT:

Background

Non-alcoholic fatty liver disease (NAFLD) is intricately linked to dysregulation of the gut-liver axis, and correlated with intestinal inflammation and barrier disruption.

Objectives

To investigate the protective effects and possible molecular mechanism of Schisantherin A (Sin A) in a high-fat diet (HFD) induced NAFLD mouse model.

Methods

HFD-fed NAFLD mice were treated with the vehicle and 80 mg/kg Sin A every day for 6 weeks. The gut permeability of the NAFLD mice was assessed by intestinal permeability assays in vivo and transepithelial electrical resistance (TEER) measurements in vitro were also used to evaluate the function of the gut barrier. TLR4 inhibitor was then used to investigate the impact of Sin A in the LPS- TLR4 signaling pathw

SUBMITTER: Yu S 

PROVIDER: S-EPMC9483129 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature