Acute high altitude exposure, acclimatization and re-exposure on nocturnal breathing.

ABSTRACT: Background: Effects of prolonged and repeated high-altitude exposure on oxygenation and control of breathing remain uncertain. We hypothesized that prolonged and repeated high-altitude exposure will improve altitude-induced deoxygenation and breathing instability. Methods: 21 healthy lowlanders, aged 18-30y, underwent two 7-day sojourns at a high-altitude station in Chile (4-8 hrs/day at 5,050 m, nights at 2,900 m), separated by a 1-week recovery period at 520 m. Respiratory sleep studies recording mean nocturnal pulse oximetry (SpO₂), oxygen desaturation index (ODI, >3% dips in SpO₂), breathing patterns and subjective sleep quality by visual analog scale (SQ-VAS, 0-100% with increasing quality), were evaluated at 520 m and during nights 1 and 6 at 2,900

SUBMITTER: Furian M 

PROVIDER: S-EPMC9483161 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature