HIV-1 pretreatment drug resistance and genetic transmission network in the southwest border region of China.

ABSTRACT:

Background

HIV drug resistance increased with the widespread use of antiretroviral drugs, and posed great threat to antiretroviral therapy (ART). Pu'er Prefecture, lying in the southwest of Yunnan Province, China, borders Myanmar, Laos and Vietnam, is also the area where AIDS was discovered earlier, however, in which there has been no information on HIV drug resistance.

Methods

A cross-sectional survey of pretreatment drug resistance (PDR) was conducted in Pu'er Prefecture in 2021. Partial pol gene sequences were obtained to analyze drug resistance and construct genetic transmission network. HIV drug resistance was analyzed using the Stanford University HIVdb algorithm.

Results

A total of 295 sequences were obtained, among which 11 HIV-1 strain types were detected and

SUBMITTER: Li D 

PROVIDER: S-EPMC9483295 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature