A review on exosomes application in clinical trials: perspective, questions, and challenges.

ABSTRACT:

Background

Exosomes are progressively known as significant mediators of cell-to-cell communication. They convey active biomolecules to target cells and have vital functions in several physiological and pathological processes, and show substantial promise as novel treatment strategies for diseases.

Methods

In this review study, we studied numerous articles over the past two decades published on application of exosomes in different diseases as well as on perspective and challenges in this field.

Results

The main clinical application of exosomes are using them as a biomarker, cell-free therapeutic agents, drug delivery carriers, basic analysis for exosome kinetics, and cancer vaccine. Different exosomes from human or plant sources are utilized in various clinical trials.

SUBMITTER: Rezaie J 

PROVIDER: S-EPMC9483361 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature