N-myc and STAT interactor is a novel biomarker of severity in community-acquired pneumonia: a prospective study.

ABSTRACT:

Objectives

To tested the ability of N-myc and STAT interactor (NMI) levels in patients with community-acquired pneumonia (CAP) to predict the severity of the disease.

Methods

Prospective observational analysis of patients with CAP was performed. The NMI levels in serum of 394 CAP patients on admission were measured by immunoassay. Thirty-day mortality and intensive care unit (ICU) admission were set as clinical outcomes. The predicting value of NMI for clinical outcomes was determined by receiver operating characteristic curve and logistic regression analysis. The internal validity was assessed using cross-validation with bootstrap resampling.

Results

NMI was an independent risk factor for both 30-day mortality and admission to ICU for CAP patients. The area under cur

SUBMITTER: Zhang W 

PROVIDER: S-EPMC9483521 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature