Temporal and Sex-Linked Protein Expression Dynamics in a Familial Model of Alzheimer's Disease.

ABSTRACT: Mouse models of Alzheimer's disease (AD) show progression through stages reflective of human pathology. Proteomics identification of temporal and sex-linked factors driving AD-related pathways can be used to dissect initiating and propagating events of AD stages to develop biomarkers or design interventions. In the present study, we conducted label-free proteome measurements of mouse hippocampus tissue with variables of time (3, 6, and 9 months), genetic background (5XFAD versus WT), and sex (equal males and females). These time points are associated with well-defined phenotypes with respect to the following: Aβ42 plaque deposition, memory deficits, and neuronal loss, allowing correlation of proteome-based molecular signatures with the mouse model stages. Our data show 5XFAD mice exhibit i

SUBMITTER: Blasco Tavares Pereira Lopes F 

PROVIDER: S-EPMC9483563 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature