The effects of acute exercise and inflammation on immune function in early-stage prostate cancer.

ABSTRACT:

Background

The immune system plays a vital role in cancer development and progression. Strategies mobilizing cytotoxic cells of the immune system to combat immunosuppression in cancer may help to improve the treatment response of patients. To this end, we aimed to characterize the anti-cancer effect of acute exercise, including the involvement of inflammatory signals.

Patients and methods

Twenty patients with early-stage prostate cancer (PCa) scheduled to undergo prostatectomy performed one bout of acute exercise consisting of a watt-max test and four high-intensity intervals. Natural Killer (NK), NKT-like and T cell phenotype, NK cell cytotoxic activity (NKCA), and NKCA per-cell against cell lines of leukemia (K562) and prostate cancer origin (LNCaP and PC-3) were assessed.

SUBMITTER: Schauer T 

PROVIDER: S-EPMC9483738 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature