Association of antipsychotic use with breast cancer: a systematic review and meta-analysis of observational studies with over 2 million individuals.

ABSTRACT:

Aims

Despite reports of an elevated risk of breast cancer associated with antipsychotic use in women, existing evidence remains inconclusive. We aimed to examine existing observational data in the literature and determine this hypothesised association.

Methods

We searched Embase, PubMed and Web of Science™ databases on 27 January 2022 for articles reporting relevant cohort or case-control studies published since inception, supplemented with hand searches of the reference lists of the included articles. Quality of studies was assessed using the Newcastle-Ottawa Scale. We generated the pooled odds ratio (OR) and pooled hazard ratio (HR) using a random-effects model to quantify the association. This study was registered with PROSPERO (CRD42022307913).

Results

Nine observ

SUBMITTER: Leung JCN 

PROVIDER: S-EPMC9483823 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature