Association between trauma exposure and respiratory disease-A Mendelian randomization study.

ABSTRACT:

Background

Trauma is a well-known risk factor for many disease, but the effect of trauma on respiratory disease is unclarified. In the present study, we aimed to evaluate the association between trauma and respiratory disease.

Method

Using both United Kingdom biobank and Finnish biobank genome-wide association study data (GWAS), we performed a two-sample Mendelian randomization (MR) analysis to evaluate the relationship between trauma and respiratory disease. We used four methods including inverse-variance weighted (IVW), weighted median, Maximum likelihood, and MR-Egger in this MR analysis. The IVW MR was selected as the main method. We also performed multivariable Mendelian randomization (MVMR) to simultaneously assess the independent impact of trauma exposure on respirato

SUBMITTER: Ma Y 

PROVIDER: S-EPMC9483852 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature