Individual HLA heterogeneity and its implications for cellular immune evasion in cancer and beyond.

ABSTRACT: Structural and functional variability of human leukocyte antigen (HLA) is the foundation for competent adaptive immune responses against pathogen and tumor antigens as it assures the breadth of the presented immune-peptidome, theoretically sustaining an efficient and diverse T cell response. This variability is presumably the result of the continuous selection by pathogens, which over the course of evolution shaped the adaptive immune system favoring the assortment of a hyper-polymorphic HLA system able to elaborate efficient immune responses. Any genetic alteration affecting this diversity may lead to pathological processes, perturbing antigen presentation capabilities, T-cell reactivity and, to some extent, natural killer cell functionality. A highly variable germline HLA genotype can co

SUBMITTER: Pagliuca S 

PROVIDER: S-EPMC9483928 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature