Long-term conditions, multimorbidity and colorectal cancer risk in the UK Biobank cohort.

ABSTRACT:

Purpose

Early identification of colorectal cancer (CRC) is an international priority. Multimorbidity (presence of ≥2 long-term conditions (LTCs)) is increasing and the relationship between CRC and LTCs is little-understood. This study explores the relationship between individual LTCs, multimorbidity and CRC incidence and mortality.

Methods

Longitudinal analysis of the UK Biobank cohort, participants recruited 2006-2010; N = 500,195; excluding previous CRC at baseline. Baseline data was linked with cancer/mortality registers. Demographic characteristics, lifestyle factors, 43 LTCs, CRC family history, non-CRC cancers, and multimorbidity count were recorded. Variable selection models identified candidate LTCs potentially predictive of CRC outcomes and Cox regression mod

SUBMITTER: Corcoran NM 

PROVIDER: S-EPMC9483970 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature