The parotid secretory protein BPIFA2 is a salivary surfactant that affects lipopolysaccharide action.

ABSTRACT:

New findings

What is the central question of this study? The salivary protein BPIFA2 binds lipopolysaccharide, but its physiological function is not known. This study uses a new knockout mouse model to explore the physiological role of BPIFA2 in the oral cavity and systemic physiology. What is the main finding and its importance? BPIFA2 is a crucial surfactant in mouse saliva. In its absence, saliva exhibits the surface tension of water. Depletion of BPIFA2 affects salivary and ingested lipopolysaccharide and leads to systemic sequelae that include increased insulin secretion and metabolomic changes. These results suggest that the lipopolysaccharide-binding activity of BPIFA2 affects the activity of ingested lipopolysaccharide in the intestine and that BPIFA2 depletion causes mild

SUBMITTER: Nandula SR 

PROVIDER: S-EPMC9484039 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature