In utero particulate matter exposure in association with newborn mitochondrial ND4L_10550A>G heteroplasmy and its role in overweight during early childhood.

ABSTRACT:

Background

Mitochondria play an important role in the energy metabolism and are susceptible to environmental pollution. Prenatal air pollution exposure has been linked with childhood obesity. Placental mtDNA mutations have been associated with prenatal particulate matter exposure and MT-ND4L_10550A>G heteroplasmy has been associated with BMI in adults. Therefore, we hypothesized that in utero PM_2.5 exposure is associated with cord blood MT-ND4L_10550A>G heteroplasmy and early life growth. In addition, the role of cord blood MT-ND4L_10550A>G heteroplasmy in overweight during early childhood is investigated.

Methods

This study included 386 mother-newborn pairs. Outdoor PM_2.5 concentrations were determined at the maternal resi

SUBMITTER: Cosemans C 

PROVIDER: S-EPMC9484069 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature