A Comparison of Operational Definitions for Mild Cognitive Impairment.

ABSTRACT:

Background

Consideration of many tests from different cognitive domains in defining mild cognitive impairment (MCI) is clinical routine, but guidelines for a neuropsychological operationalization of MCI are lacking.

Objective

Among different operational MCI criteria, to identify those which are best in predicting either conversion to dementia, or a biomarker profile indicative for Alzheimer's disease (AD).

Methods

Memory clinic patients without dementia (N = 558; mean age = 66; up to 3 years of follow-up; n = 360 with baseline CSF biomarkers) were included in an observational study using most liberal criteria of cognitive impairment. Four operational definitions of MCI were retrospectively applied: 1) amnestic MCI (CERAD word list delayed recall), 2) CERAD total score

SUBMITTER: Polcher A 

PROVIDER: S-EPMC9484125 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature