C-reactive protein and cancer risk: a pan-cancer study of prospective cohort and Mendelian randomization analysis.

ABSTRACT:

Background

Although observational studies have reported associations between serum C-reactive protein (CRP) concentration and risks of lung, breast, and colorectal cancer, inconsistent or absent evidences were showed for other cancers. We conducted a pan-cancer analysis to comprehensively assess the role of CRP, including linearity and non-linearity associations.

Methods

We analyzed 420,964 cancer-free participants from UK Biobank cohort. Multivariable-adjusted Cox proportional hazards model was conducted to evaluate the observed correlation of CRP with overall cancer and 21 site-specific cancer risks. Furthermore, we performed linear and non-linear Mendelian randomization analyses to explore the potential causal relation between them.

Results

During a median follow-u

SUBMITTER: Zhu M 

PROVIDER: S-EPMC9484145 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature