Identification of thermogenesis-related lncRNAs in small extracellular vesicles derived from adipose tissue.

ABSTRACT:

Background

Brown adipose tissue (BAT) is considered as a primary location of adaptive thermogenesis and the thermogenic activities of brown adipocytes are also connected to generating heat and counteracting obesity. Recent studies revealed that BAT could secrete certain batokines-like factors especially small extracellular vesicles (sEVs), which contributed to the systemic consequences of BAT activities. As a newly emerging class of mediators, some long non-coding RNAs (lncRNAs) have exhibited metabolic regulatory effects in adipocyte development. However, besides the well-studied lncRNAs, the lncRNAs carried by sEVs derived from brown adipose tissue (sEV-BAT) have not been identified yet.  RESULTS: In this study, we demonstrated that sEV-BAT could induce beige adipocyte differenti

SUBMITTER: Hong P 

PROVIDER: S-EPMC9484231 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature