Imaging-based body fat depots and new-onset atrial fibrillation in general population: a prospective cohort study.

ABSTRACT:

Background

Obesity is a well-established risk factor for atrial fibrillation (AF). Whether body fat depots differentially associate with AF development remains unknown.

Methods

In the prospective population-based Rotterdam Study, body composition was assessed using dual-energy X-ray absorptiometry (DXA) and liver and epicardial fat using computed tomography (CT). A body composition score was constructed by adding tertile scores of each fat depot. Principal component analysis was conducted to identify potential body fat distribution patterns. Cox proportional hazards regression was used to calculate hazard ratios and 95% confidence intervals (HR; 95% CI) per 1-standard deviation increase in corresponding fat depots to enable comparisons.

Results

Over a median follow-up

SUBMITTER: Lu Z 

PROVIDER: S-EPMC9484252 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature