Vascular mapping of the human hippocampus using Ferumoxytol-enhanced MRI.

ABSTRACT: The hippocampus is a small but complex grey matter structure that plays an important role in spatial and episodic memory and can be affected by a wide range of pathologies including vascular abnormalities. In this work, we introduce the use of Ferumoxytol, an ultra-small superparamagnetic iron oxide (USPIO) agent, to induce susceptibility in the arteries (as well as increase the susceptibility in the veins) to map the hippocampal micro-vasculature and to evaluate the quantitative change in tissue fractional vascular density (FVD), in each of its subfields. A total of 39 healthy subjects (aged 35.4 ± 14.2 years, from 18 to 81 years old) were scanned with a high-resolution (0.22×0.44×1 mm³) dual-echo SWI sequence acquired at four time points during a gradual increase in Ferumoxyto

SUBMITTER: Buch S 

PROVIDER: S-EPMC9484293 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature