Specific transcriptional programs differentiate ICOS from CD28 costimulatory signaling in human Naive CD4⁺ T cells.

ABSTRACT: Costimulatory molecules of the CD28 family play a crucial role in the activation of immune responses in T lymphocytes, complementing and modulating signals originating from the T-cell receptor (TCR) complex. Although distinct functional roles have been demonstrated for each family member, the specific signaling pathways differentiating ICOS- from CD28-mediated costimulation during early T-cell activation are poorly characterized. In the present study, we have performed RNA-Seq-based global transcriptome profiling of anti-CD3-treated naïve CD4⁺ T cells upon costimulation through either inducible costimulator (ICOS) or CD28, revealing a set of signaling pathways specifically associated with each signal. In particular, we show that CD3/ICOS costimulation plays a major role in pathw

SUBMITTER: Gigliotti CL 

PROVIDER: S-EPMC9484324 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature