Cardiac alterations following experimental hip fracture - inflammaging as independent risk factor.

ABSTRACT:

Background

Cardiac injuries following trauma are associated with a worse clinical outcome. So-called trauma-induced secondary cardiac injuries have been recently described after experimental long bone fracture even in absence of direct heart damage. With the progressive aging of our society, the number of elderly trauma victims rises and therefore the incidence of hip fractures increases. Hip fractures were previously shown to be associated with adverse cardiac events in elderly individuals, which have mainly been attributed to pre-conditioned cardiac diseases. The aim of the present study was to investigate the effect of hip fractures on the heart in healthy young and middle-aged mice.

Materials and methods

Young (12-week-old) and middle-aged (52-week-old) female C57BL/6 mi

SUBMITTER: Lackner I 

PROVIDER: S-EPMC9484325 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature