CCT3-LINC00326 axis regulates hepatocarcinogenic lipid metabolism.

ABSTRACT:

Objective

To better comprehend transcriptional phenotypes of cancer cells, we globally characterised RNA-binding proteins (RBPs) to identify altered RNAs, including long non-coding RNAs (lncRNAs).

Design

To unravel RBP-lncRNA interactions in cancer, we curated a list of ~2300 highly expressed RBPs in human cells, tested effects of RBPs and lncRNAs on patient survival in multiple cohorts, altered expression levels, integrated various sequencing, molecular and cell-based data.

Results

High expression of RBPs negatively affected patient survival in 21 cancer types, especially hepatocellular carcinoma (HCC). After knockdown of the top 10 upregulated RBPs and subsequent transcriptome analysis, we identified 88 differentially expressed lncRNAs, including 34 novel transcript

SUBMITTER: Sondergaard JN 

PROVIDER: S-EPMC9484377 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature