Viral Size Modulates Sendai Virus Binding to Cholesterol-Stabilized Receptor Nanoclusters.

ABSTRACT: Binding to the host membrane is the initial infection step for animal viruses. Sendai virus (SeV), the model respirovirus studied here, utilizes sialic-acid-conjugated glycoproteins and glycolipids as receptors for binding. In a previous report studying single virus binding to supported lipid bilayers (SLBs), we found a puzzling mechanistic difference between the binding of SeV and influenza A virus (strain X31, IAV^X31). Both viruses use similar receptors and exhibit similar cooperative binding behavior, but whereas IAV^X31 binding was altered by SLB cholesterol concentration, which can stabilize receptor nanoclusters, SeV was not. Here, we propose that differences in viral size distributions can explain this discrepancy; viral size could alter the number of virus-rece

SUBMITTER: Lam A 

PROVIDER: S-EPMC9484459 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature