Identification of a novel necroptosis-related classifier to predict prognosis and guide immunotherapy in breast invasive carcinoma.

ABSTRACT:

Background

Necroptosis plays a crucial function in the progression of breast invasive carcinoma (BRCA). It may be triggered in cancer therapy to enhance anti-tumor immunity. However, the functions of necroptosis in tumors and its relationship with the tumor microenvironment (TME) remain largely unclear.

Methods

Necroptosis-related genes (NRGs) were collated from high-quality literature reviews. A robust risk model was constructed to systematically evaluate the clinical value, functional status, effects exerted by the risk model on the TME, and the genomic variations based on the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) meta-cohorts.

Results

A risk model was constructed which comprised of six NRGs, including TNF receptor-associated factor 5 (TRA

SUBMITTER: Zhou Q 

PROVIDER: S-EPMC9484550 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature