Selection on modifiers of genetic architecture under migration load.

ABSTRACT: Gene flow between populations adapting to differing local environmental conditions might be costly because individuals can disperse to habitats where their survival is low or because they can reproduce with locally maladapted individuals. The amount by which the mean relative population fitness is kept below one creates an opportunity for modifiers of the genetic architecture to spread due to selection. Prior work that separately considered modifiers changing dispersal, recombination rates, or altering dominance or epistasis, has typically focused on the direction of selection rather than its absolute magnitude. We here develop methods to determine the strength of selection on modifiers of the genetic architecture, including modifiers of the dispersal rate, in populations that have previou

SUBMITTER: Proulx SR 

PROVIDER: S-EPMC9484686 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature