Detection of acute myocarditis by ECG-triggered PET imaging of somatostatin receptors compared to cardiac magnetic resonance: preliminary results.

ABSTRACT: Somatostatin receptors are overexpressed by inflammatory cells but not by cardiac cells, under normal conditions. This study assesses the detection of acute myocarditis by the ECG-triggered digital-PET imaging of somatostatin receptors (⁶⁸Ga-DOTATOC-PET), as compared to Cardiac Magnetic Resonance (CMR) imaging, which is the reference diagnostic method in this setting.

Methods

Fourteen CMR-defined acute myocarditis patients had a first 15-minutes ECG-triggered ⁶⁸Ga-DOTATOC PET recording, 4.4 ± 3.0 days from peak troponin, and 10 had a second 4.3 ± 0.3 months later. Myocardial/blood SUVmax ratio was analyzed relative to the normal upper limit of 2.18, which had been previously determined from oncology ⁶⁸Ga-DOTATOC-PET recordings of patients with a simi

SUBMITTER: Boursier C 

PROVIDER: S-EPMC9484840 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature