Phenolic compounds versus SARS-CoV-2: An update on the main findings against COVID-19.

ABSTRACT: The COVID-19 pandemic caused by SARS-CoV-2 remains an international concern. Although there are drugs to fight it, new natural alternatives such as polyphenols are essential due to their antioxidant activity and high antiviral potential. In this context, this review reports the main findings on the effect of phenolic compounds (PCs) against SARS-CoV-2 virus. First, the proven activity of PCs against different human viruses is briefly detailed, which serves as a starting point to study their anti-COVID-19 potential. SARS-CoV-2 targets (its proteins) are defined. Findings from in silico, in vitro and in vivo studies of a wide variety of phenolic compounds are shown, emphasizing their mechanism of action, which is fundamental for drug design. Furthermore, clinical trials

SUBMITTER: Tirado-Kulieva VA 

PROVIDER: S-EPMC9484857 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature