Regulatory Role of B Cells and Its Subsets in Hepatitis E Virus Infection.

ABSTRACT: Antibodies as well as memory B cells are the potential correlates of a protective immune response against hepatitis E virus (HEV) infection. Literature on the role of B regulatory cells (Bregs) in acute viral infections is limited. We have evaluated the role of IL-10 expressing Bregs in HEV infection. A total of 108 acute hepatitis E patients, 55 hepatitis E recovered individuals and 128 HEV naïve healthy controls were enrolled. The percentages of peripheral CD19⁺, immature CD19⁺CD24^hiCD38^hi, mature CD19⁺CD24^intCD38^int and memory CD19⁺CD24^hiCD38^- B cells were analyzed by flowcytometry. Intracellular cytokine staining for IL-10 and TGF-β, HEV-rORF2p specific T cell response (

SUBMITTER: Sharma M 

PROVIDER: S-EPMC9484887 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature