IRF9 and XAF1 as Diagnostic Markers of Primary Sjogren Syndrome.

ABSTRACT:

Objective

Primary Sjogren syndrome (pSS) is characterized by lymphocytic infiltration of the salivary and lacrimal glands. It is a chronic systemic autoimmune disease. Genetic contributions and disturbed biological systems are the two major causes of pSS, but its etiology is unclear. This study is aimed at identifying potential pSS diagnostic markers and mechanisms at the transcriptome level.

Methods

Whole blood datasets of patients with pSS were downloaded from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were identified using the online tool, GEO2R. R software was used to perform enrichment analyses to understand the functions and enriched pathways of the DEGs. A protein-protein interaction network was constructed to identify hub genes

SUBMITTER: Xiao L 

PROVIDER: S-EPMC9484944 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature