Ontology highlight
ABSTRACT:
SUBMITTER: Chhatbar K
PROVIDER: S-EPMC9485053 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Chhatbar Kashyap K Connelly John J Webb Shaun S Kriaucionis Skirmantas S Bird Adrian A
Life science alliance 20220919 12
The DNA-binding protein MeCP2 is reported to bind methylated cytosine in CG and CA motifs in genomic DNA, but it was recently proposed that arrays of tandemly repeated CA containing either methylated or hydroxymethylated cytosine are the primary targets for MeCP2 binding and function. Here we investigated the predictions of this hypothesis using a range of published datasets. We failed to detect enrichment of cytosine modification at genomic CA repeat arrays in mouse brain regions and found no e ...[more]