G3BP2 regulates oscillatory shear stress-induced endothelial dysfunction.

ABSTRACT: GTPase-activating SH3 domain-binding protein 2 (G3BP2) is a mediator that responds to environmental stresses through stress granule formation and is involved in the progression of chronic diseases. However, no studies have examined the contribution of G3BP2 in the oscillatory shear stress (OSS)-induced endothelial dysfunction. Here we assessed the effects of G3BP2 in endothelial cells (ECs) function and investigated the underlying mechanism. Using shear stress apparatus and partial ligation model, we identified that stress granule-related genes in ECs could be induced by OSS with RNA-seq, and then confirmed that G3BP2 was highly and specifically expressed in athero-susceptible endothelia in the OSS regions. G3bp2 ^-/- Apoe ^-/- mice had signi

SUBMITTER: Li T 

PROVIDER: S-EPMC9485288 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature