Decreased resting-state functional connectivity of the habenula-cerebellar in a major depressive disorder.

ABSTRACT:

Background

In animal experiments, the habenula and septal nuclei are known as the key brain areas of depression. However, there are few magnetic resonance imaging (MRI) studies on the functional connectivity between these areas and the subcortical areas in humans with major depression. We aimed to investigate the difference in resting-state functional connectivity (RSFC) among the major regions of interest (ROI) in the subcortical areas, including both the habenula and septal nuclei.

Methods

We performed the seed-to-voxel analysis to investigate the RSFC between both the habenula and septal nucleus, as well as other subcortical regions. Furthermore, ROI-to-ROI analysis was performed among the combinations of ROI pairs in the subcortical areas.

Results

The seed-to-voxe

SUBMITTER: Jung JY 

PROVIDER: S-EPMC9485485 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature