Synaptic determinants of cholinergic interneurons hyperactivity during parkinsonism.

ABSTRACT: Parkinson's disease is a neurodegenerative ailment generated by the loss of dopamine in the basal ganglia, mainly in the striatum. The disease courses with increased striatal levels of acetylcholine, disrupting the balance among these modulatory transmitters. These modifications disturb the excitatory and inhibitory balance in the striatal circuitry, as reflected in the activity of projection striatal neurons. In addition, changes in the firing pattern of striatal tonically active interneurons during the disease, including cholinergic interneurons (CINs), are being searched. Dopamine-depleted striatal circuits exhibit pathological hyperactivity as compared to controls. One aim of this study was to show how striatal CINs contribute to this hyperactivity. A second aim was to show the contrib

SUBMITTER: Padilla-Orozco M 

PROVIDER: S-EPMC9485566 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature