Dysregulation and imbalance of innate and adaptive immunity are involved in the cardiomyopathy progression.

ABSTRACT:

Background

Cardiomyopathy is known to be a heterogeneous disease with numerous etiologies. They all have varying degrees and types of myocardial pathological changes, resulting in impaired contractility, ventricle relaxation, and heart failure. The purpose of this study was to determine the pathogenesis, immune-related pathways and important biomarkers engaged in the progression of cardiomyopathy from various etiologies.

Methods

We downloaded the gene microarray data from the Gene Expression Omnibus (GEO). The hub genes between cardiomyopathy and non-cardiomyopathy control groups were identified using differential expression analysis, least absolute shrinkage and selection operator (LASSO) regression and weighted gene co-expression network analysis (WGCNA). To assess the dia

SUBMITTER: He B 

PROVIDER: S-EPMC9485579 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature